Document Type : Research Article
Author
Department of Mathematic, Payame Noor University, Tehran, Iran
Abstract
In this paper, a computational approach is adopted for solving a multi-objective optimal control problem (MOOCP) formulation of optimal drug scheduling in human immunodeficiency (HIV) virus infected by individuals. The MOOCP, which uses a mathematical model of HIV infection, has some incompatible objectives. The objectives are maximizing the survival time of patients, the level of D4+ T-cells and the level of cytotoxic T-lymphocytes (CTLs), and minimizing the viral load and the drug costs. In this approach the fuzzy goals described by the linear membership functions, are incorporated for the objectives and the optimal solution is investigated by maximizing the degree of attainment of the aggregated fuzzy goals resulting a fuzzy goal optimal control problem (FGOCP). Using the minimum operator for aggregation of fuzzy goals, the FGOCP is converted into a constrained optimal control problem (OCP) in canonical form. The control parametrization enhancing technique (CPET) is used for approximating the OCP by an optimal parameter selection problem, with the final goal of implementing continuous and interrupted (structured treatment interruptions, STI) combinations of reverse transcriptase inhibitor (RTI) and protease inhibitor (PI) drug efficacies. Efficiency of the proposed method is confirmed by numerical simulations.
Keywords
Main Subjects
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